Reus had the first real opening of the game in the 10th minute, and should have given Dortmund the lead.
Robert Lewandowski broke the deadlock against his former club after heading home from the edge of the six-yard box.
Franck Ribery nearly made it two just after the half hour, but he fired straight at goalkeeper Marwin Hitz.
A game with some incredible goals, you can relive Der Klassiker with a look at the main points of action in today's Dortmund vs Bayern clash - you'll not want to miss the wonderful second from Dortmund's Marco Reus!
But the scores were level for only three minutes. The ball dropped to Joshua Kimmich on the touchline and his lofted cutback sat up for Lewandowski to head in.
Then Achraf Hakimi squared the ball for Reus, who somehow sidefooted over the bar.
Reus should have scored his second shortly afterward, but after sidefooting past Neuer, Kimmich was on the line to clear. As the hour passed, Lewandowski thought he had grabbed a hat-trick with an angled drive into the top-left corner, but the offside flag was up.
Reus clipped another good chance wide before sweeping in a superb finish without breaking stride from a cross by Lukasz Piszczek on 67 minutes to make it 2-2.
Wait. What?! A quick glance at the table shows that Dortmund are top of the league after 11 matches and Bayern are seven points adrift!
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