Saturday, 15 June, 2019

PIO-led team develops early version vaccine for Alzheimer's

Alzheimer's disease: Possible Alzheimer's prevention breakthrough reported Researchers Working on Vaccine That Could Prevent Alzheimer's
Samantha Long | 13 June, 2019, 18:31

A vaccine that could prevent Alzheimer's disease is being worked on by University of New Mexico researchers, CBS Albuquerque affiliate KRQE-TV reported on Tuesday. "Pathological tau is one of the components of these tangles that we find in the brains of patients with Alzheimers disease".

In a paper published in the NJP -Vaccines journal, the team reported that it had successfully created a virus-like protein that had promising results in treating mice that had been bred to develop symptoms similar to those experienced by human Alzheimer's patients.

Alzheimer's disease is a progressive disorder that causes brain cells to degenerate and die. He further said that it took him about five years or more to get the idea generated and started fully working on the idea of vaccine to cure Alzheimer's disease. One in 10 people age 65 or older have suffered from Alzheimer's dementia and over 5.8 million Americans are now living with it. Scientists believe that the number is set to project to rise to almost 14 million by 2050.

Bhaskar and its team found that when the vaccine was developed to treat Alzheimer affected mice, they developed antibodies, which cleared the tau-proteins from their brains and the responses also lasts for the months. "These antibodies seem to have cleared pathological tau". The mice studied had been genetically engineered to have Alzheimer's.

Vaccinated mice were subjected to maze-like tests, and did "remarkably better" than their unvaccinated counterparts, researchers said, adding that MRI scans on vaccinated mice revealed "less brain shrinkage, suggesting that the vaccine prevented neurons from dying".

Luka Jovic on Real Madrid move
The former Barcelona and Bayern Munich manager stated this while commenting on Hazard's move from Chelsea to Real Madrid . If Spurs do offer such an amount then there's surely a reasonable chance Real Madrid will be tempted to part ways.

Virus-like proteins are created by removing the genome of a virus so it can not reproduce, leaving only a protein shell.

Maphis was pleased with test results. The shell is still recognizable as an invasive threat to the human immune system, which creates antibodies that react to and neutralize the protein shell.

Researchers said the disease is "a ideal storm of destruction in the brain", which is the result of long tangles of a protein known as tau that build up in brain neurons.

The researchers believe that their method with this specific virus-like protein may be applicable to a wider range of tauopathies, including dementia, traumatic brain injury, and chronic encephalopathy (brain disease, damage, or malfunction).

"We have to make sure that we have a clinical version of the vaccine so that we can test in people", Bhaskar says.

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