Two Trialed Drugs Show Promise in Potentially Preventing and Treating Ebola
Two Trialed Drugs Show Promise in Potentially Preventing and Treating Ebola
Boston Medical Center pathogen specialist hails new Ebola study hinting at possible cure
13 August, 2019, 18:59
"A long-running outbreak like this takes its bad toll on the affected communities, and it's a sign of just how challenging it has been to control this epidemic that there have been sufficient number of patients treated for telling us more about these four drugs' efficacy", said director of the Wellcome Trust, Dr. Jeremy Farrar.
Scientists however are hopeful that Ebola may soon be a preventable and treatable disease after promising clinical trials of two drugs which, according to expert Dr Sabue Mulangu, saw 60 per cent of the 681 patients survive.
And the Washington Post quotes Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, saying: "It's the first example that a therapeutic intervention can have a dramatic effect on decreasing the mortality of the Ebola virus disease".
"REGN-EB3 is a 3-antibody cocktail designed with the goal of enhancing efficacy, reducing the development of viral sequences that lead to resistance, and increasing potential utility in future outbreaks as viruses continually evolve", Christos Kyratsous, PhD, vice president of research, infectious diseases and viral vector technologies at Regeneron, said in a press release.
The DRC is grappling with the world's second largest Ebola epidemic on record, with more than 1,800 lives lost and over 2,600 confirmed infections since the outbreak was declared on August 1, 2018, according to the central African nation's ministry of health.
Trials like "Together Save Lives" have been introduced in areas like the Congo during outbreaks to test what treatments may be most effective for infected patients. The preliminary results in 499 study participants indicated that individuals receiving REGN-EB3 or mAb114 had a greater chance of survival compared to participants in the other two arms.
Developed with the help of antibodies harvested from Ebola survivors, mAb114 and REGN-EB3 will be used for treating patients in the Democratic Republic of Congo.
World Health Organization specialists explain that the drugs attach anti-bodies to the outside of the EBOLA virus, destroying it.
The NIAID, part of the NIH, and the Institut National de Recherche Biomedicale in the DRC jointly sponsored the trial.
"This underscores the importance of doing randomized, controlled trials. You can get ethically sound and scientifically sound information rapidly", he said.
The NIH, Democratic Republic of Congo health authorities and the World Health Organization hailed the "extraordinary team of individuals who have worked under extremely hard conditions to carry out this study", as well as the patients and their families.
The WHO's director-general has described the current outbreak as more complex than the deadlier 2014-2016 outbreak in multiple West African countries due to the region's political instability, attacks on health workers, a highly mobile population and community mistrust and misinformation.
"Getting people into care more quickly is absolutely vital", Dr. Michael Ryan, executive director of the WHO's health emergencies program, said during Monday's telephone briefing.
The trial began at the end of 2018 during the Ebola outbreak in the Democratic Republic of Congo, which is still going on and is termed as the second-largest outbreak on record.
The System Shock remake is in development for PlayStation 4, PC, and Xbox One, and will release in 2020. The ideal way to complement the System Shock remake is with an Enhanced Edition of System Shock 2 .
Sridevi famously co-starred with Anil Kapoor in Mr India nearly a decade before she married his filmmaker brother Boney Kapoor. It has nearly been a year and a half since Sridevi passed away but she yet continues to live in the hearts of her fans.
The company's gondola rides take passengers nearly 3,000 feet above sea level to see views of Howe Sound and nearby waterfalls. Nearly all of the 30 gondola cars attached to the cable crashed to the ground, according to staff working overnight.
Bolsonaro has cast himself as foe to the left-wing leaders around Latin America and celebrated his friendship with Macri. Argentina's credit default swap - or the cost of hedging bonds against sovereign default - soared to a multiyear high.
Rodriguez and some other members of the ESPN production crew were having dinner after the game when the robbery took place. Analyst Jessica Mendoza missed Sunday's game after being involved in a vehicle crash on Friday near her home in Oregon.
In March, an American man was sentenced to twenty years in prison for a similar incident that resulted in a shooting. Newly-crowned Fortnite world champion Kyle Giersdorf has been confronted by police in the middle of a game.
Fish and Wildlife Service (FWS), is to help species recover to the point that they no longer need federal protection. Several Oregon species now being considered for listing under the ESA would be subject to the new rules.
In a 21-second video, Her Royal Highness Queen Olivia Colman has announced the release date for The Crown season 3. Gillian Anderson will also reportedly be joining the fold as former Prime Minister Margaret Thatcher .
The family of Nora Quoirin has offered a reward of over 10 thousand euro for information leading to the return of their daughter. The search for the 15 year old, who's an Irish citizen, has entered its 9th day and 353 people are involved in the operation.
Conte said he would no longer accept Salvini's attacks on his ministers and accused him of relying on "slogans". It was unclear when that might happen, since parliament has adjourned for the summer holiday.
It has a dual rear camera setup accompanied with an LED flash, aligned horizontally, like the one we have seen in G8 ThinQ . But keep in mind these renders are based on leaked CAD files; they're not "official" press images from LG itself.
Iraq slams Israel participation in Gulf naval mission
Britain said last week it would join the mission, while no other USA allies have committed themselves so far. The United States wants an global coalition to monitor and potentially escort commercial ships there.
Body found in search for Nóra Quoirin
Nora's family said they were convinced she had been abducted but the Malaysian police have said there were no signs of foul play. It comes after the parents of the missing teen offered a £10,000 reward for information that could lead to her safe return.
Celtics The 2019-20 Boston Celtics schedule is announced
Kawhi Leonard and Danny Green might be gone, but what they helped accomplish can never be taken away and will long be remembered. The sixth annual Giants of Africa Game, which honours the life of Nelson Mandela, is on December 5 versus the Houston Rockets .
Red Bull: Alexander Albon to replace Pierre Gasly
Former Ipswich schoolboy Alex Albon has been given a mid-season promotion to one of Formula One's top teams. . Gasly has not just been overshadowed by Max Verstappen at Red Bull: he has experienced a total eclipse.
Severe Storms Possible Across Iowa Monday
Monday: Mostly cloudy with a few AM showers, afternoon and evening isolated storms, Overnight widespread storms. Tuesday will see highs drop back to the low 80s but showers and thunderstorms could pop up throughout the day.
Liverpool manager Klopp confirms Lonergan deal
"The situation was even more hard a few weeks ago because of injuries, but Caoimhin Kelleher is now in his final steps for being completely back", Klopp told Liverpool's official website .